Life Sciences Research

William Severson Publications

Selected peer-reviewed publications

Maddry, J.A., Jonsson, C.B., Xi, C., Ananthan, S., Poffenberger, A., Rasmussen, L., Sosa, M., White, E.L., Noah, D., Piazza, G.A. and W.E. Severson (2008) A cell based high-throughput screening approach for the discovery of new inhibitors of the influenza H5N1 virus. (manuscript in preparation)

W.E. Severson, M. McDowell, S. Ananthan, D.H. Chung, L. Rasmussen, M.I. Sosa, E.L. White, J. Noah, C.B. Jonsson. High-Throughput Screening of a 100,000 Compound Library for Inhibitors of Influenza A Virus (H3N2). J. Biomol. Screen. 13: 879-87,2008.

Severson, W.E., Shindo, N., Sosa, M., Fletcher, T., White, L. and C. B. Jonsson. (2007) Development, validation and optimization of a luminescence-based high throughput screen for inhibitors of Severe Acute Respiratory Syndrome. J. Biomol. Scr. 12:33-40

Noah, J., Severson, W., Noah, D. Rasmussen, L., White, E. L. and C. B. Jonsson. (2007) A cell based luminescence assay is effective for high throughput screening of potential influenza antivirals. Antiviral Res. 73:50-59

Severson, W.E., Xu, X., Kuhn, M., Senutovitch, N., Thokala, M., Ferron, F., Longhi, S., Canard, B. and C.B. Jonsson. (2005) Essential amino acids of the Hantaan virus N protein in its interaction with RNA. J. Virol. 79:10032-10039

Severson, W.E., Javadian, M.A., Schmaljohn, C.S. and C.B. Jonsson. (2003) Ribavirin causes error catastrophe during Hantaan virus replication. J. Virol. 77:481-488

Xu, X., Severson, W.E. and C.B. Jonsson. (2002) The RNA binding domain of the Hantaan virus N protein maps to a central, conserved region. J. Virol. 76:3301-3308

Leon, L.R, Severson, W., Thokala, M., Gallegos, J.G. and C.B. Jonsson. (2002) Purification and characterization of Hantaan virus 246 kDa RNA dependent RNA polymerase (RdRp) FASEB v.16, no.4, pt.1, p.A165-A165

Severson, W.E., Xu, X. and C.B. Jonsson. (2001) cis-Acting signals in encapsidation of Hantaan virus S-segment viral genomic RNA by its N protein. J. Virol. 75:2646-2652

Jonsson, C.B., Gallegos, J., Fero, P., Severson, W.E., Xu, X. and C.S. Schmaljohn. (2001) Purification and characterization of the Sin Nombre virus nucleocapsid protein expressed in Escherichia coli. Protein Purification and Expression. 23:134-141

Severson, W.E., Partin, L., Schmaljohn, C.S. and C.B. Jonsson. (1999) Characterization of the Hantaan N protein-ribonucleic acid interaction. J. Biol. Chem. 274:33732-33739

Severson, W.E., Mascolo, P.L., and M.W. White. (1995) Lymphocyte p56L32 is a RNA/DNA binding protein which interacts with conserved elements of the murine L32 ribosomal protein mRNA. Eur. J. Biochem. 229:426-432

Invited reviews

Jonsson, C.B., White, L., Severson, W., Noah, J. (2007) The search for promising viral targets in drug discovery. Amer. Biotech. Lab. pp.18-21

Speer, C.A., Severson, W.E., Cranston, H.J., Scollard, D., Thompson, J.R. and M.W. White. (1992) A diagnostic DNA assay for trichomoniasis in cattle. Proceedings of the Livestock Conservation Institute. pp.128-137

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