Life Sciences Research

Jorge Antonio Benitez Publications

Selected Publications

Liang, W., Syed Z. Sultan, A.J. Silva and J.A. Benitez. 2008. Cyclic AMP post-transcriptionally regulates the biosynthesis of a major bacterial autoinducer to modulate the cell density required to activate quorum sensing. FEBS Letters. 582: 3744-3750.

Silva, A. J., S. Zafar Sultan, W. Liang and J.A. Benitez. 2008. Role of the histone-like nucleoid structuring protein (H-NS) in the regulation of RpoS and RpoS-dependent Genes in Vibrio cholerae. J. Bacteriol. 190: 7335-7345

Silva, A.J., F. Eko and J.A. Benitez. 2007. Exploiting cholera vaccines as a broad application antigen delivery platform (Mini-review). Biotechnol. Letters 30: 571-579.

Liang, W., A.J. Silva and J.A. Benitez. 2007. The cAMP Receptor Protein Modulates Colonial Morphology Phase in Vibrio cholerae. Appl. Environ. Microbiol. 73: 7482-7487.

Liang, W., A. Pascual-Montano, A.J. Silva and Jorge A. Benitez. 2007. The cyclic AMP receptor protein modulates quorum sensing, motility and multiple genes that affect intestinal colonization in Vibrio cholerae. Microbiology 153: 2964-2975.

Hazra, A., A.J. Silva and J.A. Benitez. 2007. Expression of foreign proteins in a Vibrio cholerae vaccine strain using the stationary phase hemagglutinin/protease promoter. Biotechnol. Letters 29: 1093-1097.

Jahid, I.K., A.J. Silva and J.A. Benitez. 2006. Polyphosphate stores enhance the ability of Vibrio cholerae to overcome environmental stresses in a low phosphate environment. Appl. Environ. Microbiol. 72: 7043-7049.

Silva, A.J. Leitch, G.J., Camilli, A. and J.A. Benitez. 2006. Contribution of hemagglutinin/protease and motility to the pathogenesis of El Tor biotype cholera. Infect. Immun. 74: 2072-2079.

Silva, A.J. and J.A. Benitez. 2006. A Vibrio cholerae relaxed (relA) mutant expressed major virulence factors, biofilm, motility and colonized the suckling mouse intestine J. Bacteriol. 188: 794-800.

Silva, A.J. and J.A. Benitez. 2005. Th1-type immune response to a Coccidioides immitis antigen delivered by an attenuated strain of the non-invasive enteropathogen Vibrio cholerae. FEMS Immunol. Medical Microbiol 43: 393-398.

Silva, A.J. and J.A. Benitez. 2004. Transcriptional regulation of Vibrio cholerae hemagglutinin/protease expression by the cyclic AMP receptor protein and RpoS. J. Bacteriol. 189: 6374-6382.

Zhou, X., Da. Q. Gao, J. Michalski, J.A. Benitez and J.B. Kaper. 2004. Induction of Interleukin-8 in T84 cells by Vibrio cholerae. Infect. Immun. 72: 389-397.

Silva, A., Mohan, A., and J.A. Benitez. 2003. Cholera vaccine candidate 638: Intranasal immunogenicity and expression of a foreign antigen from the pulmonary pathogen Coccidioides immitis. Vaccine 21: 4715-4721.

Silva, A. and J.A. Benitez. 2003. Hemagglutinin/protease expression and mucin gel penetration in El Tor biotype Vibrio cholerae. Microbiology 149: 1883-1891.

Benitez, J.A., Silva, A. and R.A. Finkelstein. 2001. Environmental signals controlling production of hemagglutinin/protease in Vibrio cholerae. Infect. Immun. 69: 6549-6553.

Valle, E., Ledon, T., Cedre, B., Campos, J., Valmaseda, T., Rodríguez, B., Garcia, L., Marrero, K., Benitez, J.A., Rodriguez, S. and R. Fando. 2000. Construction and characterization of a non-proliferative El Tor cholera vaccine candidate derived from strain 638. Infect. Immun. 68: 6411-6418.

Benitez, J.A., L. García, A. Silva, H. García, R. Fando, B. Cedré, A. Pérez, J. Campos, B.L. Rodríguez, J.L. Pérez, T. Valmaseda, O. Pérez, A. Pérez, M. Ramírez, T. Ledón, M. Díaz, M. Lastre, L. Bravo, and G. Sierra. 1999. Preliminary assessment of the safety and immunogenicity of a new CTXF-negative, hemagglutinin/protease-defective El Tor strain as a cholera vaccine candidate. Infect. Immun. 67: 539-545.

Burgos, J.M., J.L. Pérez, L. Garcia, G.S. González, J.A. Benitez, F. Galindo, C. Silberstein, and C. Ibarra. 1999. Diarrheagenicity evaluation of attenuated Vibrio cholerae O1 and O139 strains in the human intestine ex vivo. Vaccine: 17: 949-956.

Rodriguez, B.L., A. Rojas, and J.A. Benitez. 1998. Cholera Toxin Differentially Regulates Nitric Oxide Synthesis, Tumor Necrosis Factor-α Production and Respiratory Burst in Murine Macrophages. FEMS Immunol. Medical Microbiol. 22: 193-198.

Campos, J., R. Fando, B.L. Rodriguez, A. Silva, and J.A. Benitez. 1998. Replicating functions of the RS1 element associated with Vibrio cholerae CTXΦ prophage. FEMS Microbiol. Lett. 164: 141-147.

Benitez, J.A., R.G. Spelbrink, A. Silva, T.E. Phillips, C.M. Stanley, M. Boesman-Finkelstein, and R.A. Finkelstein. 1997. Adherence of Vibrio cholerae to cultured differentiated human intestinal cells: an in vitro colonization model. Infect. Immun. 65: 3474-3477.

Fando, R., B.L. Rodriguez, J. Campos, A. Robert, J.L. Pérez, L. García, A. Silva, and J.A. Benitez. 1997. Promoter activities in the Vibrio cholerae CTXΦ prophage. Infect. Immun. 65: 1561-1565.