Preclinical Development

BSL-3/ABSL-3 Facilities

Southern Research maintains enhanced BSL-3/ABSL-3 containment facilities at its Birmingham, AL, and Frederick, MD, locations. With combined laboratory space of more than 15,000 square feet, our advanced facilities provide a highly regulated environment in which to safely study biosafety level III pathogens, agents, toxins, and select and non-select agents regulated by the Centers for Disease Control and Prevention (CDC) and the U.S. Department of Agriculture (USDA). In addition, Southern Research scientists have access to the Southeastern Biosafety Laboratory Alabama Birmingham (SEBLAB) at The University of Alabama at Birmingham (UAB).

In Vitro Capabilities

Our in vitro laboratory suites are equipped with standard equipment, including incubators, centrifuges, inverted microscopes, computers, ultra-low freezers, and refrigerators. Additional specialized equipment includes:

  • High-speed and ultracentrifuges
  • Plate readers capable of reading multiple fluorescent labels
  • Microscopic imaging system
  • Flow cytometer

In addition, the BSL-3 contains two (one for bacteria and one for viruses) laboratory suites equipped for high-throughput screening. Millions of compounds have been screened under containment.

In Vivo Capabilities

Our animal housing rooms are designed to accommodate rodents, ferrets, rabbits, and nonhuman primates. Numerous types of caging systems are available that allow for different species. All systems provide HEPA filtered exhaust. These systems include flexible film bioisolators, DuoFlows, and ventilated racks. In addition, the facilities include a complete necropsy suite to support a large variety of GLP and non-GLP preclinical studies.

Aerosol Inhalation

Also included in the ABSL-3 containment area in Birmingham is the Aerosol Inhalation laboratory, featuring an aerosol challenge suite that can be used for evaluating vaccine and drug efficacy studies as well as select agents. The aerosol challenge facility is served by a dedicated autoclave and gas decontamination chamber.

Clinical Pathology Laboratory

The BSL-3 clinical pathology laboratory, located within the BSL-3 facility, is well-equipped for the performance of routine hematology and clinical chemistry analyses on animal samples.

Southern Research maintains Standard Operating Procedures (SOPs) for transporting, receiving, processing, storing, and shipping specimens for analysis as well as for in-house chemistry and hematology assays on rodents, dogs, rabbits, ferrets, nonhuman primates, and other species. Assays are conducted using a Vetscan VS2 Clinical Chemistry Analyzer and a Hema Vet Hematology System Model HV950FS. The instrumentation utilized in the clinical pathology laboratory was selected for its accuracy, precision, and its ability to accommodate the specific characteristics of specimens from multiple nonhuman laboratory species.

Contact Us

For more information about our capabilities, contact us at:
BusDev@SouthernResearch.org
888-322-1166 (U.S.)
1-205-581-2830 (International)