Southern Research maintains a state-of-the-art High-Throughput Screening Center featuring the most advanced equipment available and a well-trained staff to ensure the highest quality of screening for our clients' research projects. The Center consists of a suite of laboratories designed for efficient screening of large (100,000 to over 1 million) compound libraries and has the capacity to run a wide variety of assay types. Our professional staff has in-depth experience and a demonstrated proficiency in transferring bench-top assays to the robotics platform and executing cell-based and biochemical screens. In addition to executing standard high-throughput screening assays, our research team is experienced in running yeast-based assays as well as assays that require BSL-2 or BSL-3 containment.
Our High-Throughput Screening Center currently conducts five large screening programs for the National Institutes of Health (NIH) and executes a number of other projects through academic or commercial collaborations. Primary research programs include:
Southern Research maintains an advanced High-Throughput Screening and Target Development program designed for rapid, target-specific analysis utilizing robotics to evaluate large compound libraries, including siRNA libraries. On a contractual basis, we offer clients access to our large compound library and our extensive expertise in screening assay-ready plates. We welcome collaborative partnerships with clients who have an interest in evaluating potential antiviral, antimicrobial, anticancer, or neurological activity on a fee-for-service or compound licensing basis.
Our High-Throughput Screening and Target Development program uses both commercially available and proprietary biochemical and cell-based screening assays. These include primary and secondary screening, hit-to-lead processes, and the subsequent optimization of lead compounds. A large inventory of primary and secondary assays is available to provide clients with an early and comprehensive profile of a compound's clinical potential.
Our laboratory is experienced in the design and development of new assays and the adaptation of current assay systems to high-throughput, automated screening systems. Our core assay system is equipped with various readers that enable us to develop assays based on our clients' choice of endpoint detection methods. Specifically, we are equipped to support clients' drug development in the following key ways:
Southern Research maintains several active collaborative research programs, and we continue to seek academic, government, and commercial research partnerships in high-throughput screening and drug discovery. We welcome collaborative opportunities in pursuit of government funding for joint efforts, including grant applications, competitive contracts, and Department of Defense Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. Using intellectual property income, Southern Research funds an in-house drug discovery program for the purpose of developing commercially relevant intellectual property.
For more information about our capabilities, contact us at: