The need for targeted, effective therapeutic treatments for central nervous system (CNS) disorders has never been greater, due in part to improved diagnosis rates and an aging population that brings a higher incidence of debilitating neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. While the complexity of the central nervous system presents unique challenges for developing novel therapies, Southern Research has a pioneering role in advancing innovative treatments for CNS disorders. Through the collective expertise of our renowned scientists, we offer clients a full range of capabilities for investigating new drugs to treat CNS disorders as well to determine the effects of a compound on the central nervous system. A unique benefit to our clients is our ability to offer comprehensive neurological research services to assess in vitro efficacy, including lead optimization to identify the most viable candidates for in vivo research.
Advanced Research and Diverse Services/Capabilities
Southern Research conducts leading-edge research in brain physiology and novel treatment agents for a range of CNS diseases including: Alzheimer's disease and other neurodegenerative disorders; mental health disorders; pain and addiction disorders; and brain tumors and traumatic brain injury. Using in vitro models of neurodegenerative disease, as well as primary astrocyte and primary neuronal cultures from all major areas of the brain, our neuropharmacology staff conducts research to discover novel effective treatment agents using well-established disease models. We provide advanced medicinal chemistry services with custom synthesis of CNS compounds; our experienced chemists have the capability to design drugs specifically for the brain. In addition, the Southern Research toxicology staff has the expertise to conduct neurotoxicity evaluations to determine the effects of a candidate drug on the central nervous system (CNS) and/or the peripheral nervous system (PNS) in adult and developing animals. These evaluations include neurobehavioral assessments as well as specialized histopathologic analyses of nervous tissues prepared by in situ perfusion.
Southern Research scientists are engaged in research involving the following CNS disorders:
The Southern Research CNS/Neurological Diseases program is comprised of the following diverse capabilities and initiatives:
For more information about our capabilities, contact us at: