Dr. Singh’s research focuses on elucidating the multiple complexities of the innate immune response to intracellular respiratory pathogens such as Francisella tularensis (Ft) utilizing a murine model of pulmonary infection. Ft, the causative agent of tularemia, is a potential bioweapon due to its ease of dissemination, multiple routes of infection, and high infectivity and lethality. No licensed vaccine is available for this disease. Tularemia is characterized by the complete absence of protective pro-inflammatory responses during the first 72 h of the infection followed by a sepsis-like syndrome that results in death in 30% – 60% of cases. The mechanisms Ft uses to evade the hostile host environment and thereby develop and maintain an intracellular niche to promote its own survival is an area of active research. A better understanding of the progression of tularemia will lead to the development of better immunotherapeutic strategies to combat this deadly disease, as well as other infections caused by respiratory intracellular pathogens.