“Emerging infections” have been defined as infections that have either newly appeared, or that have appeared previously but are expanding in incidence and geographic range, or that threaten to increase in the near future. Emerging viral diseases have threatened humanity throughout history. Changes in ecology – whether they are a result of deforestation, enhanced global transportation and commerce, or practices within a hospital—have accelerated both the emergence and spread of viruses. Sometimes outbreaks occur and then fizzle out as happened with the SARS coronavirus in 2003, while other times novel virus strains circulate globally, as occurred in the 2009 influenza pandemic or 2013-2015 Ebola pandemic. Viruses, especially the RNA viruses, can quickly adapt to and exploit these varying conditions because of the high error rates of the viral polymerases that replicate their genomes. Therefore, it comes as no surprise that the majority of the recent examples of emerging or re-emerging diseases are caused by RNA viruses. My laboratory is interested in understanding the mechanisms of viral pathogenesis at the molecular level and using this knowledge for developing new antiviral drugs. The research involves basic molecular biology and virology techniques combined with RNAi, proteomics and high-throughput screening of small molecular weight compounds.