Toxicology Services

Southern Research is committed to providing the highest quality, GLP compliant services, working with each client to design and execute fit-for-purpose studies to support regulatory submissions. We conduct preclinical safety assessment evaluations for pharmaceuticals (e.g., small molecules, vaccines, and biologics), industrial/agricultural chemicals, excipients, and other compounds.

Our Toxicology Department began more than 50 years ago and is comprised of experts in general toxicology and developmental and reproductive toxicology. Our toxicologists are supported by highly trained, experienced, and knowledgeable technical staff and an array of on-site services including histopathology, clinical pathology, immunology, and bioanalytical sciences. Southern Research routinely conducts studies using a variety of non-clinical research models and performs both model development and validation.


Study Types

• Acute, subchronic, chronic
• Carcinogenicity/Oncogenicity
• Immunotoxicology
• ADME/PK
• Developmental and Reproductive Toxicity (DART)
• Neurobehavioral testing
    o Functional observational battery
    o Morris water maze
    o Motor activity
    o Startle response
    o Neuropathology
• Multiple species
    o Rodent (mouse, rat, cotton rat, hamster, gerbil, guinea pig)
    o Ferret
    o Rabbit
    o Dog
    o Minipig
    o Nonhuman primate
    o Immunocompromised rodent
• Multiple Dose Routes
    o Oral
    o Intravenous (bolus or infusion)
    o Intramuscular
    o Intraperitoneal
    o Subcutaneous
    o Dermal
    o Intradermal
    o Intracranial/Intracerebral
    o Intrathecal
    o Intraprostatic
    o Synovial
    o Intratumoral


In-House Support Services

Bioanalytical sciences
Immunology
Infectious disease
    • BSL-2 and BSL-3 containment facilities
Pathology
    • Clinical pathology
    • Anatomic pathology (necropsy, histology, and pathology)
Anti-cancer Efficacy
Surgical services
• Quality assurance
• Project management
• Study coordination


Southern Research routinely works with a wide variety of non-clinical research models and has experience with model development and validation.
Please contact us for questions regarding your specific research needs.



How To Work With Us

As a CRO service provider, Southern Research’s Drug Development division has a straightforward business model. Contact one of our business development representatives by clicking here. A confidentiality disclosure agreement (yours or ours) will be initiated to facilitate detailed discussions around your specific needs. One of our subject matter experts will be included in the discussion to ensure we have a comprehensive understanding of your project. A proposal will then be prepared outlining the tasks to be accomplished, along with a budget and timeline. Upon acceptance of the proposal, a contract will be provided to establish the legal framework for the project.