High-Throughput Screening

Southern Research's High-Throughput Screening & Target Development Program is designed for rapid, target-specific analysis utilizing robotics to evaluate large compound libraries. This assay development program uses both commercially available and proprietary biochemical and cell-based screening assays. These include primary and secondary screening, state-of-the-art, hit-to-lead processes, and the subsequent optimization of lead compounds. A large inventory of primary and secondary assays is available to provide clients with an early and comprehensive profile of a compound's clinical potential.

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Assay Design and Optimization

Our laboratory is experienced in the design and development of new assays and the adaptation of current assay systems to high-throughput, automated screening systems. Our core assay system is equipped with various readers that enable us to develop assays based on your choice of endpoint detection methods. More specifically, we are set up to support your drug development in the following ways:

• Design of assay systems for your target of interest
• Development and optimization of high-throughput screens
• Adaptation and optimization of existing assays to high-throughput screens
• Technical support for your assay development personnel

One of our unique capabilities is our ability to run HTS screens with BSL3 pathogens. We welcome collaborations with companies that need access to a large compound library and have an interest in evaluating potential antiviral, antimicrobial, neurological anticancer, or neurological activity on a fee for service or compound licensing basis.

Snapshot of Southern Research's HTS Experience (2005 - 2008)

BSL2 Targets	BSL3 Targets
Influenza (Udorn)	Severe Acute Respiratory Syndrome Coronavirus (SARS)
Respiratory Syncytia Virus	West Nile Virus
Herpes Simplex Virus	Highly Pathogenic Avian Influenza (H5N1)
Blue Tongue Virus	Mycobacterium tuberculosis H37Rv
HIV Latency	Select Agent Authorized
Staphylococcus aureus
Streptococcus pneumonia
Escherichia coli
Yersinia pestis
Saccharomyces cerevisiae

High-Throughput Screening
HTS Informatics
HTS Equipment
HTS Publications
HTS Virtual Poster Session
Chemical Repository

News Coverage

• November 1, 2007 - HTS Hits the Jackpot (Drug Discovery & Development)
• June 5, 2007 - Launching an HTS Campaign to Discover New Antivirals (European Pharmaceutical Review 86KB, PDF format)

Contact:
David R. Harris
Director of Strategic Business Development
205-581-2343
d.harris@southernresearch.org