Cancer

In Vivo Antitumor Evaluations

Southern Research is a recognized pioneer in anti-cancer drug development drawing on the unique expertise gained from a relationship with the National Cancer Institute since 1957. We have screened thousands of potential anti-cancer compounds, including most of the FDA-approved drugs, and developed a proprietary database that includes efficacy information on most clinically active agents. Our unparalleled experience allows us to optimally design studies that provide critical preclinical efficacy data for your regulatory application. We provide responsive and experienced study directors with years of experience performing preclinical efficacy studies in immune-compromised and immune-competent mice.

We can help you advance your product by conducting the following evaluations:

• Antitumor efficacy models
• Early vs. late stage disease comparisons
• Evaluations to maximize compound effectiveness
• Establishment of maximum tolerated dose
• Determination of schedule dependency
• Comparison of formulations and routes of administration
• Determination of minimum effective dosage
• Combination chemotherapy with clinically useful agents or radiation
• Cross resistance profiles
• Spectrum of activity analyses

We offer tumor model development and use of the existing models (>100 available) including:

• Human tumor xenografts in athymic nude or SCID mice (>80 available):
• Breast
• CNS
• Colon
• Head and Neck
• Kidney
• Leukemia/Lymphoma
• Liver
• Lung
• Ovarian
• Pancreatic
• Prostate
• Skin (Melanoma)
• Uterine
• Orthotopic tumor xenograft models:
• Breast
• CNS
• Kidney
• Prostate
• Syngeneic mouse models
• Breast
• Colon
• Kidney
• Leukemia (sensitive and corresponding drug-resistant models)
• Lung
• Melanoma
• Pancreatic
• Metastasis models
• Xenograft
• Syngeneic
• Specialized models
• Angiogenesis
• Arthritis
• Tolerance studies
• Chemoprevention
• Gene therapy
• In vivo immunology
• Radiation-induced oral mucositis
• Related services:
• In vitro cytotoxicity screening including the NCI 60 cell line screen
• I.V. (internal and external pump) S.C. and I.P. infusions in mice
• Tissue sample collection for PK and PD analysis
• Working with ³H and ¹⁴C labeled compounds
• Histology
• Pathology
• Clinical Chemistry
• Immunology

Our staff has extensive experience in a wide variety of specialized techniques and delivery methods to optimally test your compounds. Our facilities are AAALAC-accredited and can house 18,000 mice.